Ziconotide
N-type calcium channel blocker peptide for intrathecal severe pain (specialist-only).
Overview
Not a systemic analgesic — implanted pump delivery with psychiatric monitoring.
What it is
Synthetic cone snail peptide ω-conotoxin MVIIA.
Mechanism (high level)
Blocks presynaptic N-type calcium channels in spinal cord — potent analgesia with CNS risks.
Quick facts
- Dosage
- Titrate intrathecally per pain specialist
- Route
- Intrathecal infusion
- Cycle
- Long-term pump therapy when indicated
- Storage
- Hospital pharmacy handling
Research indications
- Severe refractory pain (intrathecal)
Research protocols (education)
Education-first logging template
Use PepTok to track adherence and notes; any protocol must be directed by a qualified clinician.
Interactions
Often avoided with
- Psychiatric instability without clearance
- oral opioid reliance assumptions
Often combined with
- Multidisciplinary pain program
Requires implanted intrathecal access — never SubQ/IV recreationally.
Side effects & safety
- Confusion, psychosis, meningitis risk — emergency care for new neuro symptoms.
Regulatory notes
- FDA-approved intrathecal product (Prialt) in the US; Rx-only.
FAQ
Is this a prescription?
PepTok does not provide prescriptions; it is for logging and education.
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Educational content only. This material is not medical advice. Verify legality, sourcing, and dosing with a qualified professional.